A 73 year old woman presents witha 2.5 cm firm thyroid nodule, with no palpable neck nodes. She is asymptomatic. FNA is described as "suspicious for papillary carcinoma". She adamantly refuses any surgical treatment of any kind. What is the best second line treatment? I expect little would be accomplished with I-131 in view of the bulk of thyroid tissue. Besides intense thyroxine suppression, what else is there?